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Parameter sensitivity analysis was performed to understand the impact of ointment formulation changes on ocular exposure. The model uses the following parameters: application surface area (SA), a fitted application time, and the fitted Higuchi release constant to characterize the rate of passage of the active pharmaceutical ingredient from the ointment formulations into the tears in vivo. MethodsĪ newly OCAT™ model developed for fluorometholone, as well as a previously verified model for dexamethasone, were used to characterize the aqueous humor (AH) concentration following the administration of multiple ointment formulations to rabbit.

Eltrombopag is used with standard immunosuppressive therapy for the first-line treatment of patients aged 2 years and older with severe aplastic anaemia.The purpose of this study is to show how the Ocular Compartmental Absorption & Transit (OCAT™) model in GastroPlus ® can be used to characterize ocular drug pharmacokinetic performance in rabbits for ointment formulations.

Trifarotene is a retinoid analogue used topically in the treatment of acne vulgaris of the face and body.

Teprotumumab is a recombinant human monoclonal antibody, directed against the insulin-like growth factor-1 receptor, used for the treatment of thyroid eye disease (Graves’ ophthalmopathy).

Lumateperone is an atypical antipsychotic used for the treatment of schizophrenia.Elexacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector used with ivacaftor and tezacaftor in the treatment of cystic fibrosis in patients who have at least one F508del mutation in the CFTR gene.Crizanlizumab is a human immunoglobulin G2 monoclonal antibody, that binds to P-selectin, used to reduce the frequency of vaso-occlusive crises in sickle-cell disease.Proprietary Preparations and Manufacturers updated for the following countries and regions: Entries for the European Pharmacopoeia have been updated for Ph Eur 10.Updated names, synonyms and codes official standards official preparations: Upadacitinib is an orally active Janus kinase inhibitor used in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and atopic eczema.Ozanimod is an immunomodulator used in the treatment of relapsing forms of multiple sclerosis and ulcerative colitis.Inclisiran is a double-stranded, small interfering ribonucleic acid (siRNA) conjugate used in the management of heterozygous familial and non-familial hypercholesterolaemia and mixed dyslipidaemia.Difelikefalin is a kappa-opioid receptor agonist used in the management of moderate to severe pruritus associated with chronic kidney disease in haemodialysis patients.Avapritinib is a tyrosine kinase inhibitor used in the treatment of gastrointestinal stromal tumours and systemic mastocytosis.

Stockley’s Herbal Medicines Interactions.Drug Administration via Enteral Feeding Tubes.Dale and Appelbe’s Pharmacy and Medicines Law.Martindale: The Complete Drug Reference.Clarity’s Diagnosis and Treatment Guidance.